Introduction: How to accelerate the drug development process? What kind of weapon can solve the bottleneck of drug development? How to develop modern new drugs in valuable and abundant natural medicine resources? The proliferation of macromolecules such as monoclonal antibodies, vaccines, and recombinant proteins is exploding. Do you expect to develop new drugs as soon as possible to occupy a place? Molecular Devices offers a complete solution for the most critical steps in the drug development process. Drug screening is the testing and testing of preliminary pharmacological activities of substances that may be used as medicinal substances. For innovative drugs, screening is an indispensable means and approach. In particular, the competition for contemporary innovative drug research is very intense. The focus of competition lies in the screening of new drugs. Low-cost and high-efficiency screening of new drugs is the core of the problem. It is the process of shortening the discovery of new drugs. Molecular Devices is committed to providing innovative solutions for traditional small molecule and macromolecular drug development. Its products are known in the industry for its high throughput, cost saving, high automation, high stability, easy operation and use, and are recognized by the industry as a leader in high-throughput drug screening technology. GPCRs drug development and screening GPCRs have become the first major target for drug screening. The GPCRs superfamily has a total of 600-1000 proteins and is the largest known molecular target protein with therapeutic potential. Currently, 40% of drug screening is for screening of GPCRs, and more than 50% of commercially available drugs are effective through GPCRs. GPCRs have become the first major target for drug screening. GPCRs are coupled to G proteins, and G proteins (GTP-binding proteins) contain three subunits: α, β, and γ, forming a trimer. The different subtypes of Gα, Gαs, Gαi and Gαq, activate different biological effects. Therefore, the detection of biological products produced after activation can achieve the purpose of screening GPCRs. There are many screening methods for GPCRs on the market, including isotope labeling, fluorescent labeling, antibody labeling, and the like. Through unremitting efforts, Molecular Devices has also made a unique contribution to drug screening for GPCRs. I. Method of detection by Gq path: Download the original to learn more Soft Bandages,Cotton Bandages,Medical Bandages,First-Aid Plaste Bandage Zhende Medical Co.,Ltd , https://www.zdmedicalproducts.com
1. Intracellular calcium ion concentration change fluorescence detection method 2. HTRF IP1 detection method 2. Detection method by Gi and Gs pathway:
1. Detect changes in intracellular calcium concentration by LiveWare Cell Lines 2. CatchPoint® cAMP assay 3. Screen all types of GPCRs by morphology
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