Release date: 2015-05-19

If you only need to inject a vaccine once, you can live a flu for a lifetime. How good it is. Now scientists seem to have found the key to making this vaccine.

Researchers at Fudan University and the University of Melbourne have found that immune cells that kill the flu can remember the virus strain. The study was published in the May 13 issue of Nature Communications. The author of the article was a researcher at Jianqing Xu of Fudan University and Katherine Kedzierska of the University of Melbourne.

According to reports, this discovery can help people develop a life-long effective flu vaccine. The British "Daily Mail" introduced this topic "Is this the end of the flu season?"

When the body encounters a new flu virus, it will send "killer" CD8+ T cells, which can remember the flu strain they have encountered, said Katherine Kedzierska, an associate professor at the University of Melbourne.

In 2013, the bird flu virus H7N9 caused many infections and deaths in China. This is a bird flu virus that can infect humans, with a hospitalization rate of 99% and a mortality rate of 30%. Although the spread of the virus is finally controlled, if the H7N9 gains the ability to pass people, it will cause a large-scale epidemic, and millions of people may die.

"We found that people who could not produce 'flu killer' T cells were facing death after collecting patient samples. We can develop protective vaccines based on these T cells," Kedzierska said.

Understanding the mechanisms of action of these "killer" cells can help people develop vaccine components that are resistant to all new strains and achieve lifelong protection by injecting a universal flu vaccine. The study can also help clinicians predict the patient's immune system's response to the virus so that interventions can be taken in a timely manner, especially when the patient is at risk.

About the Author:

Dr. Xu Jianqing, Researcher, Center for Infectious Diseases and Public Health, Institute of Biomedical Research, Fudan University, Research Fellow, Fudan University, Research Fellow, Associate Dean, Director of Scientific Research Department, Shanghai (Fudan University) Public Health Clinical Center, Infectious Disease Prevention, China CDC Control the National Key Laboratory PI. Editors of Emerging Microbes and Infection, Plos One, Chinese Medicine (English), Chinese Preventive Medicine, and Chinese Journal of Laboratory Medicine. He graduated from the Chinese Academy of Medical Sciences & Peking Union Medical College with a Ph.D. in 1997, and later joined the American Institute of Genetics and Human Therapy for postdoctoral work.

In early 2004, he returned to China to carry out work, continued to engage in vaccine research and development, immunization strategy research, HIV/AIDS clinical immunology research for HIV strains in China, and gradually carried out immunological research on influenza infection.

Apply for three international patents: one is the new AIDS treatment strategy “intermittent therapy”, and the other is the therapeutic vaccine DermaVir, the universal influenza vaccine method.

The projects hosted include: 2 major national science and technology projects on infectious diseases, 1 natural science fund and 1 project on the surface; and 973 projects.

He has published more than 70 SCI research papers in journals such as Science, PNAS, Clin Infect Dis, Neurology, Biomaterials, AIDS, J Virol, and EID.

Source: Biopass

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