Release date: 2015-05-13

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Recently, Kallistem, based in Lyon, France, announced that they had successfully developed fully functional human sperm for the first time in the laboratory at the end of last year. The researchers removed the immature spermatogonia from the male testis and converted the genetic material to form mature sperm. These sperms can be used for in vitro fertilization or cryopreservation.

Kallistem Laboratories is a private research center that says the study will conduct human clinical trials within two years; if the trial is successful, the company hopes to treat 50,000 patients a year, valued at 1.7 billion euros. This breakthrough is expected to help thousands of infertile men.

Company CEO Isabelle Cuoc said in an interview: "Kallistem is working to solve the major problems affecting countries around the world: male infertility treatment. Our team developed the world's first technology to allow fully formed sperm in vitro. Kallistem Targeting the global market of billions of euros."

However, before the publication of the related patent Artisem on June 23, Kallistem refused to release any results. It is also because the research has not been published, reviewed and verified, and many experts have expressed doubts about the breakthrough results released last Friday.

Allan Pacey, a professor at the University of Sheffield, is an expert in male fertility. In an interview with Daily Mail, he said: "A claim like this will always bring hope to those who are infertile, but in the end these studies cannot be translated into The available treatments will make these couples even more disappointed."

Previous related research

In a study published in the journal Nature in February 2011, researchers led by reproductive biologist Takehiko Ogawa of Yokohama City University in Japan removed the testes of young rats born two or three days and placed the testes One contains a dedicated medium. The researchers then allowed the testicles to grow.

About a month later, the researchers noticed that the testes looked quite normal and were producing sperm. Subsequently, the researchers extracted sperm and artificial insemination of the female, when the pregnant female had produced 12 healthy mice. Using the same method, the researchers were able to produce sperm from young testes that had been frozen for 1 month.

On January 3, 2012, according to the British "Daily Telegraph" website, German and Israeli researchers extracted germ cells that control sperm production from mouse testis and placed them in a special compound composed of agarose gel. In order to create an environment similar to the growth of sperm in the testis, we finally succeeded in breeding healthy sperm with fertility.

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In a study published in the journal Cell on December 24, 2014, scientists not only induced skin cells completely into inducible stem cells (iPS) in vitro, but also differentiated them into human primordial germ cells (hPGCLC). The first step to help build human sperm and eggs; and found the key gene for hPGCLC in vitro - SOX17 gene and marker substance - CD38 glycoprotein.

Source: Bio-Exploration

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